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formula for sample size n. E margin of error. N population size e Margin of error percentage in decimal form z z-score.
S Z 2 P Q E 2. SS Z 2 p 1 p C 2. If your population is smaller and known just use the sample size calculator.
The formula for the sample size can be written mathematically as follows.
Where n required sample size in each group m1is the mean change in pain score from baseline to week 24 in Drug A 5 m2is the mean change in pain score from baseline to week 24 in Drug B 45 the clinically important difference m1-m2 05 s is the standard deviation 1195. N population size e Margin of error percentage in decimal form z z-score. The sample size n can be calculated using the following formula. Where n required sample size in each group m1is the mean change in pain score from baseline to week 24 in Drug A 5 m2is the mean change in pain score from baseline to week 24 in Drug B 45 the clinically important difference m1-m2 05 s is the standard deviation 1195.