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how to calculate log p. Hydrophobicity as determined by logP can help explain or predict the behavior of a compound and is useful in many industries. The P that provides the best fit is taken to be the measured P value which is reported as the logarithm ie.
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Value is a constant defined in the following manner. The distribution coefficient log D is the ratio of the sum of the concentrations of all forms of the compound ionized plus un-ionized in each of the two phases one essentially always aqueous. As such it depends on the pH of the aqueous phase and log D log P for non-ionizable compounds at any pH.
P log10 Partition Coefficient Partition Coefficient P organicaqueous Where indicates the concentration of solute in the organic and aqueous partition.
This set is based on the data set in Viswanadhan et al. It has been shown for compounds to have a reasonable propability of being well absorbt their logP value must not be greater than 50. It has a role as a non-steroidal anti-inflammatory drug a non-narcotic analgesic a cyclooxygenase 2 inhibitor a cyclooxygenase 1 inhibitor an antipyretic a xenobiotic an environmental contaminant a radical scavenger and a drug allergen. Antilog Calculation Comin Right UpSubscribe Suggest for morePlanning to upload more Education videos related to 12th Science Please support.
